Results of the high-value case biological test analyses between very high TPMT activity patients and other patients with normal and low TPMT activity.

Global approach: a low-value case is defined as at least one occurrence, over the study period, of biological test result below the low threshold defined in Table 1. Frequency-based approach: for a given patient, the frequency of low-value encounters is defined as the number of encounters with at least one occurrence below the low threshold divided by the number of encounters (mean low-value encounter frequencies are reported). TPMTa: thiopurine S-methyltransferase activity. lowTPMTa: low TPMTa (<8.5 nmol/h/mL red blood cells); vhTPMTa: very high TPMTa (≥15.0 nmol/h/mL red blood cells); nTPMTa: normal TPMTa (in between).