Histone arginine methylation by Prmt controls lung branching morphogenesis through transcriptional repression of Bmp

We report that a protein arginine methyltransferase Prmt and symmetric dimethylation at histone H arginine (HRsme) directly associates with chromatin of Bmp to suppress its transcription. Inactivation of Prmt in the lung epithelium results in halted branching morphogenesis, altered P-D airway patterning and neonatal lethality. The sample are E14.5 mouse lung ,for each sample, seven lungs were collected and pooled.The Control sample is E14.5 wildtype lung. Total RNA was extracted from these two samples and performed RNA-sequencing.