Nickel Catalyzed Selective Arylation of Geminal Dinitriles: Direct Access to α‑Cyano Carbonyl Compounds
收藏NIAID Data Ecosystem2026-05-01 收录
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The catalytic intermolecular arylation of disubstituted geminal dinitriles with in situ generated arylnickel complexes is disclosed. This method efficiently provides various all-carbon substituted α-cyanocarbonyl compounds without additives and an inert atmosphere. It also demonstrates the arylation of R-BINOL and S-BINOL derived geminal dinitriles, preserving optical purity. Mechanistic studies proved that the in situ generated organonickel complex is involved in arylation.
创建时间：
2024-02-07
