Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (miRNA-seq dataset). Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (miRNA-seq dataset)

The goals of the study are to compare differently expressed genes in heart tissues of hypertensive rats (spoutaneously Hypertension Rats, SHR) with age-matched control rats (wistar Rats, WKY), identify new targets to reverse hypertension induced cardiac remodeling and idetify the targets of Traditional Chinese Medicine QDG. Overall design: RNA sequencing was performed with heart tissue of NS or QDG treated SHRs and WKY Rats (n = 6 for each group) to identify the differently expressed genes and related pathway.