Genome-wide analysis of long non-coding RNAs involved in nodule senescence in Medicago truncatula

In this study, lncRNAs in mature and aging nodules were investigated by high-throughput strand-specific RNA-seq. A total of 4576 lncRNAs and 126 differently expressed lncRNAs (DElncRNAs) were identified. Interestingly, the largest sub-set of differently expressed target genes of DElncRNAs were associated with membrane component. Of these, nearly half genes were related to material transport, suggesting that an important function of DElncRNAs during nodule senescence is the regulation of substance transport across membranes.