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Proteomics on colorectal cancer MCTS upon OXPHOS inhibition

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NIAID Data Ecosystem2026-03-11 收录
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https://www.omicsdi.org/dataset/pride/PXD016495
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Previous high throughput gene expression profiling combined with a HCT116 colon cancer tumor spheroid-based drug-screening assay identified context-dependent treatment responses to OXPHOS inhibitors resulting in a shunting towards the mevalonate pathway. To complement these findings with a characterization of the proteome we use mass-spectrometry based proteomics to investigate protein profiles and context-dependent treatment responses in PMCTS and QMCTS compared to monolayer cells.
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2020-07-29
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