CyP60 chaperones Basigin

Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway.

Basigin作为一种细胞外环孢素的信号受体，发挥着重要作用。已有研究表明，环孢素60（Cyp60），作为环孢素家族中的一种独特成员，参与调节Basigin的细胞内运输。该活动机制涉及Cyp60与预测的跨膜结构域Basigin内部或相邻的含脯氨酸区域相互作用。Cyp60在质膜上与Basigin共定位，暗示Cyp60可能作为伴侣蛋白，陪伴Basigin通过分泌途径。