MBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain

ChEBI2015-07-30 更新2026-07-12 收录

强直性肌营养不良机制

RNA毒性作用

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-68890 数据链接链接失效反馈

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资源简介：

MBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain

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2015-07-30

Crystal structure of CUG repeat RNA duplex containing A-U base pair and U-U mismatches

RNA结构生物学

强直性肌营养不良机制

Crystal structure of CUG repeat RNA duplex containing A-U base pair and U-U mismatches Descriptor: RNA (5'-R(P*UP*UP*CP*UP*GP*CP*AP*GP*CP*UP*GP*AP*A)-3'), RNA (5'-R(P*UP*UP*CP*UP*GP*CP*UP*GP*CP*UP*GP*

Protein Data Bank Japan2023-11-29 更新50

Crystal structure of CUG repeat RNA duplex containing U-U mismatches

RNA结构生物学

强直性肌营养不良机制

Crystal structure of CUG repeat RNA duplex containing U-U mismatches Descriptor: RNA (5'-R(P*UP*UP*CP*UP*GP*CP*UP*GP*CP*UP*GP*AP*A)-3') Authors: Wang, S.C, Satange, R.B, Hou, M.H. Deposit date: 2022-0

Protein Data Bank Japan2023-11-29 更新30

Alternative splicing and gene expression defects in motorneurons derived from DM1 hiPSCs and MBNL knockouts hiPSCs generated by CRISPR/Cas9.

神经肌肉接头病理

强直性肌营养不良机制

Myotonic dystrophy type I (DM1) is the most frequent neuromuscular disease (NMD) in adults and only symptomatic treatments have been proposed to patients. DM1 has long been defined by muscular defects

NIAID Data Ecosystem10

Mice Lacking MBNL1 and MBNL2 Exhibit Sudden Cardiac Death and Molecular Signatures Recapitulating Myotonic Dystrophy

强直性肌营养不良机制

心脏性猝死小鼠模型

Myotonic dystrophy (dystrophia myotonica, DM) is caused by expansions of CTG (type 1; DM1) or CCTG (type 2; DM2) repeats in the non-coding regions of the DMPK and CNBP genes, and patients with DM1 or

NIAID Data Ecosystem50

Ares Swanson MBNL mutant study

强直性肌营养不良机制

组织RNA分析

MBNL1 is a known splicing factor and is related to Myotonic Dystrophy (DM). This study examines the tissue specific splicing patterns of MBNL1 using a mutant and wild type mouse across three tissues (

NIAID Data Ecosystem30

MBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain

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