THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003).

细胞膜招募的 AKT 在苏氨酸和丝氨酸上的磷酸化过程，可以被两种不同的蛋白质直接结合所抑制。其一为C端调节蛋白（THEM4，即CTMP），该蛋白与AKT的羧基端尾巴结合（Maira et al. 2001）；其二为 Tribbles 同源蛋白 3（TRIB3），该蛋白与 AKT 的催化结构域结合（Du et al. 2003）。