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Transcription profiling of human liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms

ChEBI2008-06-16 更新2026-07-21 收录

脂肪肉瘤分子病理学

端粒维持机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-8046 数据链接链接失效反馈

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资源简介：

Transcription profiling of human liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms

应用场景：

创建时间：

2008-06-16

端粒维持机制

端粒酶调控

Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and chromosome end protection. We previously showed that Arabidopsis thaliana POT1a

NIAID Data Ecosystem90

ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2

端粒维持机制

ALT细胞端粒生物学

Telomeres are the ends of linear chromosomes and together with the shelterin complex present an essential feature for genome integrity. Vertebrate telomeres usually consist of hexameric TTAGGG repeats

NIAID Data Ecosystem70

TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA in lung tumor organoids. TGS1 in human telomerase capping

端粒维持机制

肺癌肿瘤类器官

Pathways that direct the selection of the telomerase-dependent or recombination-based, alternative lengthening of telomere pathway (ALT) in cancer cells are poorly understood. Using human lung tumor o

NIAID Data Ecosystem30

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

干细胞模型

端粒维持机制

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the presence of short telomeres at presentation. Mutations in ten different genes, whose products are involved

NIAID Data Ecosystem70

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

端粒维持机制

DNA修复

Telomerase-independent ALT (alternative lengthening of telomeres) cells are characterized by high frequency of telomeric homologous recombination (HR), C-rich extrachromosomal circles (C-circles) and

NIAID Data Ecosystem60

Transcription profiling of human liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms

资源简介：

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