Genome-wide DNA Methylation and Transcriptome Analysis of Non-invasive and Invasive Melanoma Cell Lines (RRBS)

Melanoma is a very aggressive type of skin cancer, which renders it difficult to treat because of extensive heterogeneity frequently observed in melanoma tumours. Here we hypothesized that gene expression and DNA methylation differences would correlate with invasiveness in melanoma cells. To address this question, we carried out genome-wide transcriptome and methylome investigations in non-invasive and invasive groups of melanoma cell lines. We generated methylation profiles of 12 cell lines (10 samples + 2 technical replicates) which included non-invasive cell lines, invasive cell lines and melanocyte cell lines