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Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and BPA stress human neural stem cells(hNSC) Transcriptomes

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185138
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Bisphenol A (BPA) is a common industrial chemical widely used to produce various plastics and is known to impair neural stem cells (NSCs). However, the effects of low-dose BPA exposure on the stemness maintenance and differentiation fate of NSCs remain unclear in the infants brain. Here we demonstrated that 1 μM BPA promoted human NSC proliferation and stemness, and didn’t significantly increase cell apoptosis. The Chip-seq experiments demonstrated that both the cell cycle and the TGF-beta signaling pathway were accelerated under the 1 μM BPA condition. Human neural stem cells mRNA profiles by 1 μM bisphenol A
创建时间:
2021-10-03
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