首页/数据集/Two-fold elevation of endogenous GDNF levels enhances and maintains motor and dopaminergic function without causing side-effects until high age

Two-fold elevation of endogenous GDNF levels enhances and maintains motor and dopaminergic function without causing side-effects until high age

Mendeley Data2019-10-11 更新2026-04-09 收录

神经退行性疾病治疗

GDNF基因疗法

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https://data.mendeley.com/datasets/87cdnsjcgz/1 数据链接链接失效反馈

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资源简介：

Raw data of the experiments included in the manuscript

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创建时间：

2019-10-11

发育分子机制

神经退行性疾病治疗

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RNA-seq of a small molecule targeted recruitment of a ribonuclease to degrade the c9ALS/FTD r(G4C2) repeat expansion

神经退行性疾病治疗

RNA降解

We are publishing a study of a small molecule targeted recruitment of a ribonuclease to degrade the c9ALS/FTD r(G4C2) repeat expansion. We performed multiple RNA-seq experiments to evaluate the effect

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神经退行性疾病治疗

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The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Deve

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis

神经退行性疾病治疗

激酶抑制剂开发

Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhi

NIAID Data Ecosystem40

Two-fold elevation of endogenous GDNF levels enhances and maintains motor and dopaminergic function without causing side-effects until high age

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