mRNA sequencing-based DEGs: Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

Introduction: Diabetic nephropathy (DN), as a complication of diabetes, is one of the major causes of end-stage renal disease. Licochalcone B (LCB), a flavonoid active component derived from licorice, is well known for its anti-inflammatory and antioxidant properties. However, the influence of LCB on DN remains unclear. This research investigated the effect of LCB on DN and elucidated the regulatory mechanism.
Methods: We employed male C57BL/6 mice to construct a DN mouse model induced by a high-fat diet (HFD)/streptozotocin (STZ). In vitro, a high glucose (HG)-induced injury model in HK-2 (human renal tubular epithelial) cells was used to further confirm the protective effects of LCB.
Results: LCB treatment (20 mg/kg and 40 mg/kg) decreased blood glucose levels, kidney injury, glycogen deposition, and collagen accumulation in the DN mice. Moreover, LCB at a dosage of 40 mg/kg reduced albumin, creatinine, and blood urea nitrogen levels by about 70.7%, 33.4%, and 45.6%, respectively, ind..., , # Data from: mRNA sequencing-based DEGs: Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

Dataset DOI: [10.5061/dryad.zkh1893r3](https://doi.org/10.5061/dryad.zkh1893r3)

## Description of the data and file structure

The variables of the data file includes: Access number of the genes followed by the gene symbol, full information of the gene, gene expression expressed in log2(fold change). The data presented in this dataset provides information of the high-throughput mRNA sequencing-based DEGs in article “Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice”.In brief, mice were reared with high-fat diet (HFD) for four weeks before being intraperitoneally injected with streptozotocin (STZ) for five days. Following STZ administration, mice in the treatment groups received LCB via gavage once every two...,