A cell cycle-based functional screen to identify lncRNA-based cancer biomarkers. Homo sapiens
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA357034
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资源简介：
We report S-phase cancer associated lncRNAs which were identified using nascent RNA capture assay in HeLa cells. Coupling high throughput RNA sequencing with clinical investigation across TCGA datasets we identified a number of lncRNAs that act as prognostic biomarkers for survival in different cancer types Overall design: The differential expression levels of S-phase specific lncRNAs across TCGA datasets were assessed. The clinical values of the differentially expressed lncRNAs were predicted using Kaplan-Meir, univariate and multivariate Cox regression analysis. Functional characterization for different lncRNAs was done using knockdown strategies followed by RNA-seq
创建时间：
2016-12-12
