Fig4_own_sensitivity_dataset_cisplatin

Raw dose-response growth curves to cisplatin of various breast cancer cell line models. Corresponding results files calculating drug sensitivity parameters according to Hafner et al. 2016.
File names in ‘Parameters’ files
‘[…]_CellNr’ / ‘[…]_Conf’ Analysis performed on Fluorescent Channel (Cell Number) or Confluence Channel (Conf).‘[…]_1/2/3’ Analyzed replicate --> replicate whose initial confluence is closest to 20%.
Excel sheets in ‘Parameters’ files
Fitting of 4-day dose-dependent growth curves to exponential function:
‘exp_k’ exponential growth rate for each condition (fitting of 4-day growth curves to exponential function)‘exp_CIlow’ / ‘exp_CIup’ confidence intervals of the exponential growth rate.‘exp_Rsq’ Rsq-value of each exponential fit. Calculation of doubling times from final and initial values of the time-series:
‘doublingtime’ doubling time in hours‘doublingtime_std’ standard deviation of doubling times, propagated from standard deviation across two technical replicates.Fitting of sigmoidal function to dose-dependent exponential growth rates (as described in Hafner et al.,2016)
‘parameters’ cleaned growth rate inhibition parameters —> “drug-sensitivity parameters”‘parameters’ dose eliciting a GRinf response (not used in the manuscript but extracted alongside).