A cancer stem cell hierarchy based on differential ribosomal RNA and protein synthesis capacities [EPHB2]

Ribosomal RNA (rRNA) transcription and protein synthesis are heterogeneously regulated in colorectal tumors and are gradually shut down during cell differentiation. Cancer stem cell hierarchy and tumor growth is defined by a tumor cell population that displays elevated rRNA and protein synthesis. Tumor cells expressing different levels of EPHB2 were isolated from fresh surgically resected CRC samples