To determine role of RIPK4-LATS-YAP/TAZ axis in skin differentiation, RNAseq of human keratinocyte cell line under distinct differentiation and genetic conditions was performed.

NIAID Data Ecosystem60

Interpretable deep learning reveals the sequence rules of Hippo signaling (ChIP-Seq). Interpretable deep learning reveals the sequence rules of Hippo signaling (ChIP-Seq)

Hippo信号通路

转录因子结合位点分析

How specific cells respond to signaling pathways is largely encoded in the DNA sequence. However, the sequence rules result from complex interactions between signaling and cell-type-specific transcrip

NIAID Data Ecosystem60

ASPP2 Links the Apical Lateral Polarity Complex to the Regulation of YAP Activity in Epithelial Cells

细胞极性调控

Hippo信号通路

The Hippo pathway, by tightly controlling the phosphorylation state and activity of the transcription cofactors YAP and TAZ is essential during development and tissue homeostasis whereas its deregulat

NIAID Data Ecosystem80

Regulation of gene expression by loss-of-YAP/TAZ in MCF10A mammary epithelial cells. Homo sapiens

转录调控机制

Hippo信号通路

YAP1 (Yes-associated protein 1) and TAZ (transcriptional coactivator with PDZ-binding motif, or WWTR1) are nucleo-cytoplasmic shuttling proteins that can function in the nucleus as transcriptional coa

NIAID Data Ecosystem60

ARHGAP9 ONTARGETPlus LM2, no change in YAP:TAZ ratio (2).bmp

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