Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis

Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality. Overall design: In order to explore the effect of Becn1 on megakaryocytes in mice.We then performed gene expression profiling analysis using data obtained from RNA-seq of megakaryocytes in Becn1f/f and Becn1f/f ;Pf4-iCre mice.