FeaSion Uncovers the Multifaceted Co-transcriptional Roles of RNAPII CTD Phosphorylation Regulated by Cancer Hallmark Genes

We utilize the FeaSion (Feature-Screening-Function) strategy to investigate five known phosphorylation states (pY1, pS2, pT4, pS5, pS7) of RNAPII. Our study demonstrates that mutations at these phosphorylation sites broadly influence transcriptional and co-transcriptional processes. And regulators of these sites involve various biological processes.