Effect of LRRK2 inhibitors on IFN-γ-induced expression of CD14, CD16 and MHC-II by monocytes.

For each inhibitor IC50 obtained on LRRK2 WT kinase enzyme activity is indicated (Deng et al., 2011; Nichols et al., 2010). Is indicated the percentage +/− SD of CD14+, CD16+ or MHC-IIhigh cells obtained after IFN-γ treatment (30 IU/mL) in presence of 1 or 10 µM of LRRK2 inhibitors. In all experiment DMSO concentration has been fixed to 0.1%. (a p<0.05, c p<0.005, One way Anova with Bonferroni post test). N indicates the number of independent experiment for each tested compound. ND: Not determined.