a4b7 Integrin signaling (v2.0)

This is the updated version of an original NCI Pathway Interaction Database (PID) network.
The list of entities (genes, proteins, chemicals, etc) from the original network was used to query the INDRA database, retrieving high-quality relationships between entities. INDRA is a database that integrates information from multiple high-quality text mining engines, pathway databases, and small molecule resources. The INDRA-derived relationships are up-to-date and have links to detailed summaries of supporting literature evidence, including the specific supporting text.
While we have included only high-confidence relationships, text-mining complicated sentences can produce errors such as the reversal of up-regulation vs. down-regulation or the direction of an edge (i.e. B activates A instead of A activates B). Nevertheless, the entity recognition by the text miners is excellent and the text supporting a relationship almost always describes a genuine relationship between the entities.
Legend:
BLUE: edges annotated by INDRA only.
RED: edges annotated both by INDRA and PID.
YELLOW: selected element.