Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

Pharmacological activation of hypoxia-inducible factor 1alpha (HIF-1α), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced exosome production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased exosome levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased exosome production may be involved in the pleiotropic effects of HIF-1 activators., , , # Data from: Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

[https://doi.org/10.5061/dryad.c866t1gdq](https://doi.org/10.5061/dryad.c866t1gdq)

This README file was generated on 2024-04-09 by Kohei Fujii.

GENERAL INFORMATION

1. Title of Dataset:
Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T cadherin

2. Author Information
A. Corresponding author Contact Information
Name: Yuya Fujishima M.D., Ph.D. and Shunbun Kita, Ph.D.
Institution: Osaka University
Address: 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan
Email: [[e-mail]](mailto:[e-mail]).

3. Date of data collection (single date, range, approximate date): 2017-2023

4. Geographic locati...