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Inhibition of Medulloblastoma growth by a sonic hedgehog (SHH) inhibitor

ChEBI2016-03-14 更新2026-07-12 收录

母细胞瘤靶向治疗

SHH信号通路抑制剂

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-77042 数据链接链接失效反馈

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资源简介：

Inhibition of Medulloblastoma growth by a sonic hedgehog (SHH) inhibitor

应用场景：

创建时间：

2016-03-14

母细胞瘤靶向治疗

PROTAC药物机制

MZ1 is a newly designed pan-BET-targeting PROTAC that binds to target proteins (BET proteins such as BRD2, BRD3, and BRD4) and recruits them to the ubiquitin/protease pathway for selective destruction

NIAID Data Ecosystem70

TABLE 2 from SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma

母细胞瘤靶向治疗

药物联合疗效评估

Treatment regimens administered to Kelly xenografts

Figshare2023-12-27 更新60

Additional file 2 of The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma

母细胞瘤靶向治疗

MYCN抑制剂机制研究

Additional file 2.

DataCite Commons2022-05-01 更新50

Targeting transcription-replication conflicts is an effective therapeutic principle for MYCN-driven neuroblastoma [ChIPseq_IMR5_RNAseqH1]

母细胞瘤靶向治疗

转录复制冲突

Targeting the function of MYC proteins for therapy is a major challenge in tumor biology. MYC proteins are transcription factors that can globally release RNA polymerase II (RNAPII) from core promoter

NIAID Data Ecosystem60

TABLE 2 from SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma

母细胞瘤靶向治疗

化疗耐药机制

Treatment regimens administered to Kelly xenografts

NIAID Data Ecosystem50