Molecular mechanism of small peptide from Periplaneta americana against H2O2-induced KGN apoptosis. Homo sapiens(human)

Granulosa cells (GC) are an important somatic component of the ovary and are critical for follicular development by supporting developing oocytes, proliferating and producing sexual steroids and various growth factors. Apoptosis of follicular granulosa cells is the main cause of follicular atresia. Oxidative stress (H2O2) can lead to apoptosis of granulosa cells and oocytes, resulting in follicular atresia and a decline in female reproductive function. Therefore, it is expected to provide a new strategy for the treatment of premature ovarian failure to find a substance that can significantly inhibit the apoptosis of human ovarian granulosa cells.