Amastigote susceptibility (IC50) of the in vitro resistance selection procedure to PMM-MIL combination therapy.
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No difference was observed between IC50 of the wild-type strain (LEM3323 WT) and the strains that underwent three (LEM3323 PMM/MIL3) or five (LEM3323 PMM/MIL5) repeated exposures to the combined high concentrations of PMM and MIL. Exposure to 5 treatment cycles with either PMM (LEM3323 PMM) or MIL alone (LEM3323 MIL) revealed a clear decrease in drug susceptibility (indicated in bold) [21].
创建时间：
2017-05-25
