Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
收藏PubMed Central1993-02-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC45906/
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资源简介：
When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle crystals formed. Electron microscopic analysis of these needle crystals revealed that they are composed of stacks of triple-stranded helices with each strand of the helix made up of subunits of hemagglutinin-neuraminidase. To our knowledge, this is the first direct demonstration of the assembly of protein subunits into large triple-stranded helices. An understanding of the organization of these triple helices may shed light on the structural properties of the hemagglutinin-neuraminidase molecules that cause them to form these helices. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-02-15
