High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8+ T Cells
收藏NIAID Data Ecosystem2026-04-29 收录
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https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002441.v1.p1
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资源简介：
We developed a high-dimensional, tetramer associated T cell receptor sequencing (TetTCR-SeqHD) method to simultaneously profile cognate antigen specificities, TCR sequences, targeted gene-expression, and surface protein expression. Cultured antigen-specific CD8+ T cell clones were studied as a proof-of-concept experiment. In addition, both the antigen specific CD8+ T cells from healthy subjects and Type I diabetic patients were investigated. 18 individually consented subjects pooled into four groups for sample processing]]>
PBMCs from healthy subjects and Type I diabetic patients were included in the study.
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创建时间：
2021-05-25
