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scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection

NIAID Data Ecosystem2026-03-11 收录

CD8+T细胞耗竭

肿瘤与慢性病毒感染免疫

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122713 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2019-03-25

T细胞耗竭表观遗传学

肿瘤与慢性病毒感染免疫

Epigenetically similar subpopulations of exhausted CD8+ T-cells are found in chronic viral infection and tumors ATAC-Seq analysis of progenitor exhausted and terminally exhausted CD8+ T-cells isolated

NIAID Data Ecosystem60

CD8+ T-cell exhaustion induced by leukemic cells drives progression in Chronic Lymphocytic Leukemia

慢性淋巴细胞白血病免疫

CD8+T细胞耗竭

Mechanisms mediating to disease progression from diagnosis in chronic lymphocytic leukemia (CLL) are not fully elucidated. The acquisition of molecular changes at the time of progression has been obse

NIAID Data Ecosystem30

Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8 + T Cells and Efficiently Reduces Chronic Retroviral Loads

慢性病毒感染免疫

CD8+T细胞耗竭

Chronic infections with human viruses, such as HIV and HCV, or mouse viruses, such as LCMV or Friend Virus (FV), result in functional exhaustion of CD8+ T cells. Two main mechanisms have been describe

NIAID Data Ecosystem20

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

COVID-19

CD8+T细胞耗竭

The molecular properties of CD8+ T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8+ T cells, obtained us

NIAID Data Ecosystem60

Transcriptome differences in HCC infiltrated CD8+ T cells in effector and exhaustion state. Transcriptome differences in HCC infiltrated CD8+ T cells in effector and exhaustion state

肿瘤免疫微环境

CD8+T细胞耗竭

CD8+ T cells isolated from HCC tissue were divided into three groups: PD1-TIM3- CD8+ TILs, exhibiting full effector function; PD1-intTIM3+ CD8+ TILs, exhibiting partial exhaustion; and PD1-hiTIM3+ CD8

NIAID Data Ecosystem20

scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection

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