Gene expression profile at single cell level of primary neuronal culture from cortices of C57Bl6 and hTau mice treated with pathogenic brain-derived Tau oligomers

Primary cortical neurons are established tool to study Tau oligomers-mediated toxicity. We used single-cell RNA seq to identify diverisity of gene expression upon Tau oligomers treatment Overall design: Primary cortical neurons have been isolated from embrionic brains from two mouse models C57 (wt) and hTau and their RNAs analyzed according to the treatement with Tau oligomers