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Multicomponent Synthesis of 1,3-Diketone-Linked N‑Substituted Pyrroles, Pyrrolo[1,2‑a]pyrazines, Pyrrolo[1,4]diazepines, and Pyrrolo[1,4]diazocines

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Figshare2019-01-10 更新2026-04-29 收录
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A new methodology is developed for the efficient synthesis of 1,3-diketone-linked N-substituted pyrroles, pyrrolo­[1,2-a]­pyrazines, pyrrolo­[1,4]­diazepines, and pyrrolo­[1,4]­diazocines in good yields via a Yb­(OTf)3-catalyzed, nitromethane-mediated reaction of primary amine/diamine, furfural, and 1,3-diketone. Possible mechanisms for these multicomponent reactions are also proposed.

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2019-01-10
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