Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth

ChEBI2011-05-03 更新2026-07-21 收录

耐药性前列腺癌

PTEN基因功能

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-29010 数据链接链接失效反馈

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Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth

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2011-05-03

Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer (Affymetrix). Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer (Affymetrix)

耐药性前列腺癌

激素受体靶向治疗

Constitutively active androgen receptor (AR) signaling confers resistance to AR-targeted therapies. Here we show that the ubiquitin-mediated proteolysis pathway plays a critical role in the degradatio

NIAID Data Ecosystem50

RNA-seq analysis regarding antiandrogen (enzalutamide) effect on gene expression in castration-resistant prostate cancer (CRPC) xenograft model

耐药性前列腺癌

RNA测序基因表达分析

VCaP prostate cancer xenografts grown in castrated mice were treated with antiandrogen (enzalutamide), and samples were obtained during treatment response (Enza I: 5 days after initiation of the treat

NIAID Data Ecosystem20

Transcriptional responses of control and MDV3100 resistant lines to DMSO or MDV3100

耐药性前列腺癌

转录组药物响应

Transcriptional responses of control and MDV3100 resistant lines to DMSO or MDV3100

ChEBI2013-09-30 更新10

Supplementary Data S12 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

耐药性前列腺癌

肿瘤基因组学

Supplementary data 12 describes the GSEA analysis of resistant samples vs baseline samples from patients with acquired resistance

Figshare2023-07-19 更新40

RB-N phosphorylation promotes BRD4-mediated CREB signaling hyperactivation and BET inhibitor resistance

耐药性前列腺癌

靶向治疗联合方案

The combination of CREB inhibitor and JQ1 could overcome the resistance to BET inhibitors in RB loss prostate cancer. Our study firstly showed that GNB1L-CREB pathway was activated after RB loss and c

NIAID Data Ecosystem20

Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth

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