HMPA

The Human MicroPeptide Atlas (HMPA) is a resource identifying 19,586 novel cancer-associated micropeptides from proteomic reanalysis of 3,753 samples across 8 cancers. It catalogs 3,065 dysregulated micropeptides (370 prognostic), employs deep learning to build a micropeptide-protein interaction network, and provides insights into micropeptide functions as bioactive molecules in cancer biology.

搜集汇总

背景与挑战

背景概述

HMPA是一个专注于人类癌症中非经典蛋白质组学的数据库，特别针对微肽（micropeptides）进行大规模注释和分析。它基于多组学数据构建，包含19,586个微肽条目、3,753个蛋白质组学样本，并覆盖多种癌症类型，提供微肽的基本信息、结构预测、功能网络及临床预后指标。该数据库旨在帮助研究人员深入探索微肽在癌症中的表达模式和潜在生物功能。