OECD Environment, Health and Safety Publications Series on the Safety of Manufactured Nanomaterials No. 58
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InordertoderivehealthbasedReferenceValuesfromtheresultsoftoxicologicalstudies,assessmentfactors-alsotermedsafetyoruncertaintyfactors-areappliedtoarelevantstartingpoint(orpointofdeparture)whichcanbeaNOAEL1oraBMDL52observedintheparticularstudy.AttheWorkshoponRiskAssessmentofManufacturedNanomaterialsinaRegulatoryContext(16-18thSeptember,2009)inWashingtonD.C.,UnitedStatesofAmerica,itwasconcluded,followingdiscussion,thattheapplicationofstandarduncertaintyfactorsappliedintheassessmentofchemicalstotheriskassessmentofnanomaterialsshouldundergovalidationandthatajustificationshouldbeprovidedwhenusinguncertaintyfactorscurrentlynotvalidatedfornanomaterials(ENV/JM/MONO(2010)10).
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