Targeting Sex Determination to Suppress Mosquito Populations
收藏NIAID Data Ecosystem2026-03-14 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA942966
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资源简介：
We previously developed a precision-guided Sterile Insect Technique (pgSIT) approach, which leveraged the CRISPR-Cas9 technology to simultaneously disrupt two genes essential for female viability and male fertility during the development and generate sex-sorted and sterilized males. In this work, we show that CRISPR-Cas9 can be used to simultaneously disrupt three genes in Ae. aegypti, dsx, intersex (ix), and beta-Tubulin 85D (betaTub), resulting in female lethality or masculinization and nearly complete male sterility.
创建时间：
2023-03-09
