Hv1 Mediated H+ Permeability

Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.

细胞内碱化对于启动运动、成熟化、超激活以及顶体反应至关重要。 Hv1介导可兴奋膜的电压依赖性质子通透性。 Hv1在人类精子的鞭毛主要部分中大量表达，使其处于理想的位置以激活轴丝中的pH依赖性蛋白，从而控制精子的运动。