Changes in cortical parameters in the distal femur diaphysis from wild type and Igf1-null mice, treated or untreated with PTHrP (1–36) or osteostatin.

T.Ar, total area; Ct.Th, cortical thickness; J, polar moment of inertia. Nt, PTHrP (1–36); Ost, osteostatin. Values are mean±SEM corresponding to 2 males and 4 females for PTHrP-treated mice or 3 males and 3 females for vehicle-treated mice of each genotype, respectively. Kruskall-Wallis was used to compare differences among all groups, and Mann-Whitney test for comparison between 2 groups. *pvs vehicle-treated wild type (WT).