Oncostatin M neutralization in E. coli pneumonia. Oncostatin M neutralization in E. coli pneumonia

Oncostatin M (OSM) is an IL-6 family cytokine that is necessary for neutrophil recruitment in pneumonia by inducing STAT3-dependent production of CXCL5. We used microarrays to identify additional pathways affected by OSM neutralization in the lungs during pneumonia. Overall design: We sought to understand the effect of the cytokine OSM on whole lung RNA in the early stages of E. coli pneumonia. Mice were infected for 6 hours with E. coli plus control or neutralizing anti-OSM antibody.