Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization [Hi-C]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE226015
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We employed CRISPR knock-in with a sensitive PCR-based screening strategy to precisely engineer cells with mutant MED12 Gly44. Critically, the engineered myometrial SMC cells recapitulate several UF-like cellular, transcriptional and metabolic alterations, including enhanced proliferation rates in 3D spheres and altered Tryptophan/kynurenine. metabolism We performed High-throughput chromosome conformation capture (Hi-C) in MED12-WT and MED12-G44 mutant hTERT uterine smooth muscle cell to understand the 3D genome compartmentalization
创建时间：
2023-09-12
