Supplementary materials: MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke

These are peer-reviewed supplementary materials for the article 'MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: Search termsSupplementary Table 2: Studies excluded for potential population selection biasSupplementary Table 3: Study and patient baseline characteristics at the study levelSupplementary Table 4: Combined (EmboTrap, Trevo, and Solitaire) ordinal mRS scores across treatment groups.Supplementary Results 1: Ordinal mRS scores at 90 daysSupplementary Results 2: Core-lab subanalysis:Supplementary Results 3: Prospective-only subanalysis.Supplementary Table 5: Comparison of recanalization outcomes between EmboTrap®, Trevo, and Solitaire among studies with outcomes adjudicated by a core-laboratory.Supplementary Table 6: Comparisons of functional, safety, and recanalization outcomes between EmboTrap®, Trevo, and Solitaire among prospective studies.Supplementary Figure 1: Outlier and influence analyses of rates of mRS 0-2 at 90 daysSupplementary Figure 2: Forest plot of comparisons of mRS 0-2 at 90 days.Supplementary Figure 3: Forest plot of comparisons of mRS 0-2 at 90 days.Supplementary Figure 4: Outlier and influence analyses of rates of mortality at 90 daysSupplementary Figure 5: Forest plot of comparisons of mortality at 90 days.Supplementary Figure 6: Forest plot of comparisons of mortality at 90 daysSupplementary Figure 7: Outlier and influence analyses of ENT ratesSupplementary Figure 8: Forest plot of comparisons of ENT/distal emboli.Supplementary Figure 9: Outlier and influence analyses of sICH rates.Supplementary Figure 10: Forest plot of comparisons of sICH.Supplementary Figure 11: Forest plot of comparisons of complete or near-complete recanalization on first pass (FPR mTICI ≥2c).Supplementary Figure 12: Forest plot of comparisons of successful recanalization on first pass (mFPR mTICI ≥2b).Supplementary Figure 13: Forest plot of comparisons of final complete recanalization (TICI 3).Supplementary Figure 14: Forest plot of comparisons of final successful recanalization (mTICI ≥2b).Supplementary Figure 15: Forest plot of comparisons of complete or near-complete recanalization on first pass (FPR mTICI ≥2c) among core-lab adjudicated studies.Supplementary Figure 16: Forest plot of comparisons of successful recanalization on first pass (mFPR mTICI ≥2b) among core-lab adjudicated studies.Supplementary Figure 17: Forest plot of comparisons of final complete recanalization (TICI 3) among core-lab adjudicated studies.Supplementary Figure 18: Forest plot of comparisons of final successful recanalization (mTICI ≥2b) among core-lab adjudicated studies Supplementary Figure 19: Forest plot of comparisons of successful recanalization on first pass (mFPR mTICI ≥2b) among prospective studies.Supplementary Figure 20: Forest plot of comparisons of final complete recanalization (TICI 3) among prospective studies.Supplementary Figure 21: Forest plot of comparisons of final successful recanalization (mTICI ≥2b) among prospective studies.Supplementary Figure 22: Forest plot of comparisons of ENT/distal emboli among prospective studies.Supplementary Figure 23: Forest plot of comparisons of sICH among prospective studies.Supplementary Figure 24: Forest plot of comparisons of mRS 0-2 at 90 days among prospective studies.Supplementary Figure 25: Forest plot of comparisons of mortality at 90 days among prospective studies.Aim: Stent-retriever (SR) thrombectomy has demonstrated superior outcomes in patients with acute ischemic stroke compared with medical management alone, but differences among SRs remain unexplored. We conducted a Systematic Review/Meta-Analysis to compare outcomes between three SRs: EmboTrap , Solitaire™, and Trevo. Methods: We conducted a PRISMA-compliant Systematic Review among English-language studies published after 2014 in PubMed/MEDLINE that reported SRs in ≥25 patients. Functional and safety outcomes included 90-day modified Rankin scale (mRS 0-2), mortality, symptomatic intracranial hemorrhage (sICH), and embolization to new territory (ENT). Recanalization outcomes included modified thrombolysis in cerebral infarction (mTICI) and first-pass recanalization (FPR). We used a random effects Meta-Analysis to compare outcomes; subgroup and outlier-influencer analysis were performed to explore heterogeneity. Results: Fifty-one articles comprising 9,804 patients were included. EmboTrap had statistically significantly higher rates of mRS 0-2 (57.4%) compared with Trevo (50.0%, p = 0.013) and Solitaire (45.3%, p