Supplementary material corresponding to the article 'free cortisol and free 21-deoxycortisol in the clinical evaluation of congenital adrenal hyperplasia'

Supplementary material corresponding to the article ‘Free cortisol and free 21-deoxycortisol in the clinical evaluation of congenital adrenal hyperplasia’ (DOI: 10.1210/clinem/dgae591) published in The Journal of Clinical Endocrinology & Metabolism (JCEM).

This study aimed to measure free cortisol and free 21-deoxycortisol concentrations in patients with congenital adrenal hyperplasia and compare this to levels in patients with non-classic congenital adrenal hyperplasia, patients with other forms of adrenal insufficiency, and controls.

This collection includes the supplementary materials:

- Table S1: Genetic analyses of included CAH patients (n=34) with predicted phenotype based on residual enzyme activity and literature.
- Table S2: liquid chromatography tandem mass spectrometry setting for measuring total cortisol and 21-deoxycortisol
- Table S3: liquid chromatography tandem mass spectrometry setting for measuring total cortisol and 21-deoxycortisol
- Figure S1: Flowchart of included patients for this research
- Figure S2: Percentage of free cortisol before (T0) and after (T60) administration of Synacthen® in patients with classic congenital adrenal hyperplasia (CAH), non-classic congenital adrenal hyperplasia (NCCAH), adrenal insufficiency but not CAH (AI), and controls. (S2A) Free cortisol percentage at T0; (S2B) Change in free cortisol percentages between T0 and T60; (S2C) Free cortisol percentage at T60.
- Reference list of the references used in this document.