KIT kinase domain in complex with a pyrrolopyrimidine-based compound (17)

KIT kinase domain in complex with a pyrrolopyrimidine-based compound (17) Descriptor: 4-[4-[5-(phenylmethyl)pyrimidin-2-yl]piperazin-1-yl]-7~{H}-pyrrolo[2,3-d]pyrimidine, Mast/stem cell growth factor receptor Kit Authors: Scrima, A, Mueller, M.P, Rauh, D. Deposit date: 2025-11-27 Release date: 2026-07-15 Last modified: 2026-08-19 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nat Commun, 17, 2026