Camelus bactrianus

We leveraged the high-throughput data generated by Miseq sequencing of the variable domains of the antibody heavy chains from three Bactrian camels to conduct in-depth comparative analyses of the immunoglobulin repertoire. These include analyses of the complementary determining region 3 (CDR3) length and distribution, mutation rate, antibody characteristic amino acids, the distribution of the cysteine (Cys) codons and the non-classical VHHs.For the first time, a relatively complete picture of the Bactrian camel antibody immune repertoire including conventional antibody (Ab) and HCAbs has been depicted through PCR and in silico analysis based on high-throughput sequencing data.