MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
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https://www.ncbi.nlm.nih.gov/sra/SRP172755
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资源简介：
In this study, we identify MBNL1 as a unique molecular vulnerability across MLL-rearranged leukemias. Through transcriptomic profiling and novel splicing analyses of MLL-rearranged leukemia cell lines following shRNA knockdown of MBNL1, we show that MBNL1 regulates alternative splicing (predominantly intron retention) of genes essential to MLL-rearranged leukemogenesis, such as DOT1L and SETD1A. Overall design: Identification of MBNL1-dependent alternative splicing in MLL-fusion leukemia by RNAseq of MOLM-13 cells
创建时间：
2020-05-20
