Structure of human SHP2 in complex with inhibitor IACS-13909

Structure of human SHP2 in complex with inhibitor IACS-13909 Descriptor: 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 Authors: Leonard, P.G, Joseph, S, Rodenberger, A. Deposit date: 2020-05-04 Release date: 2021-03-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res., 80, 2020