SPUR-MTDL Experimental Data: High-Resolution Mass Spectrometry, NMR (¹H & ¹³C), Rodent Behavioral & Transgenerational Assays, Bisulfite Sequencing, and Molecular Docking (Walter W., Substrate Decentralized Bio-Research, 2026) - Kathmandu Lab Site 021

Supporting dataset for the preprint: SPUR-MTDL: Sudden Propagating Unification Reactor Multi-Directional Ligand — Synthesis, Characterization, and Ontological Reduction of Ego-Centric Neural Architecture via Heritable Cooperative Plasticity (Walter W. / Substrate Decentralized Bio-Research, January 2026) Preprint available at: https://independent.academia.edu/WalterWBioResearch This dataset contains experimental and supporting data for SPUR-MTDL (C₅₇H₇₀N₄O₉, MW 955.20 Da), a convergent multi-target directed ligand (MTDL) designed to integrate Dihexa-inspired neurotrophic signaling, ALTO-100-derived epigenetic modulation, and phenethylamine-based monoaminergic tuning. Files include:- HRMS (Orbitrap ESI+, [M+H]+ 955.5215, Δ = 0.6 ppm)- ¹H NMR (600 MHz, DMSO-d₆) and ¹³C NMR (150 MHz, DMSO-d₆) spectra (CSV & PNG)- 2D COSY correlation matrix (CSV)- Rodent behavioral data (F0 baseline & F1 transgenerational emotional intelligence scores, CSV)- Bisulfite sequencing FASTQ files (SPUR lineage & control, methylation % drop from 66.2% to 44.8%)- TrkB molecular docking structure (PDB)- Summary statistics (JSON: n values, p-values, EC₅₀s, etc.)- README.md with file overview and citation guidance All data supports in vitro claims of 500–550% synaptogenesis enhancement, 150–250% BDNF upregulation, 80 to 90% EI improvement, 90% pro-social signaling increases (IL-10, oxytocin, vasopressin, serotonin), and heritable epigenetic modifications (offspring EI +45%, p<0.001), with XOR-gated BDNF/HGF pathway redundancy (EC₅₀ 0.18 nM / 1.05 nM). Animal studies compliant with Swiss Federal Act on Animal Protection (TSchG) and EU Directive 2010/63/EU (protocol SR-2023-08-NCE, NCEB-Zurich). Human survey data (n=85) under informed consent (IRCS-Geneva, protocol IRCS-2024-142-WW). License: CC-BY 4.0 International Citation: Walter W. (2026). Supporting Dataset for SPUR-MTDL [Dataset]. Pre-Print of the Paper Can be Viewed Here: https://www.academia.edu/146179107/A_Ligand_for_Heritable_Emotional_Intelligence_Enhancement_SPUR_MTDL_In_Vitro_Characterization_and_Synthesis