Global transcriptomic analysis of placenta from women with gestational SARS-CoV-2 infection during the 3rd trimester of pregnancy

Transcriptomic analysis of the placenta in both maternal and fetal compartments was performed to investigate the impact of maternal SARS-CoV-2 infection. Overall design: 16 placental samples from women immediately after term delivery were collected, of which seven had confirmed SARS-CoV-2 infection by PCR before parturition. Extracted total RNA from placental tissues, separately from maternal and fetal compartments, constructed cDNA libraries, and sequenced them to assess mRNA and small RNA expression.