Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection

Chronic allograft rejection is an insurmountable obstacle to long-term allograft survival. Donor-specific anti-HLA antibodies play an important role in causing chronic antibody-mediated allograft rejection. Historical and current evidence from the literature supports the hypothesis that HLA are unreliably immunogenic but definitively antigenic. We hypothesized that anti-HLA antibodies may develop following viral superinfection., The NETRAD algorithm is described in \"ANTI-HLA ANTIBODIES MAY BE A SUBSET OF POLYREACTIVE IMMUNOGLOBULINS GENERATED AFTER VIRAL SUPERINFECTION,\" pending review for publication as of (2025) Transplant Immunology, manuscript #TRIM-D-24-00351 and also under United States provisional patent application as \"SYSTEM AND METHOD FOR DETERMINING AND DEVELOPING MONOCLONAL ANTIBODIES AS BIOMARKERS FOR DIAGNOSTIC TARGETS AND THERAPEUTIC APPLICATIONS.\" Patent pending., , # Data from: Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection

[https://doi.org/10.5061/dryad.qjq2bvqpq](https://doi.org/10.5061/dryad.qjq2bvqpq)

### Change Log:
Version dated January 30, 2025 was modified to correct typing errors and epitope naming designations in 5 files: NETRAD_CompleteDataforPublishing, 6-HLA-B1302_Influenza_EBV_Epitopes, 6-HLA-DR4_H3N2_EBV_Epitopes, 6-HLA-C0401_H1N1_EBV_Epitopes, 1-CumulativeHLAepitopes.

File 6-HLA-B1302_Influenza_EBV_Epitopes had epitope naming convention modified from 76EN to 44MA after identifying epitope specificity correction. File 6-HLA-C0401_H1N1_EBV_Epitopes had epitope naming convention modified from 156RA to 156R after identifying epitope specificity correction. File 6-HLA-DR4_H3N2_EBV_Epitopes had epitope naming convention changed from 80VV to 80V after identifying epitope specificity correction. All epitope specificities align with the HLA Eplet Registry ([https://epregistry.com...