Trough concentrations of oxycodone and its metabolites.

Abbreviations: N, number of patients; Ratio (D3 to D1), the ratio of the geometric mean trough concentration of CR oxycodone plus aprepitant on day 3 to those of CR oxycodone alone on day 1; Ratio (D3 to D2), the ratio of the geometric mean trough concentration of CR oxycodone plus aprepitant on day 3 to those of CR oxycodone alone on day 2. Geometric mean (% coefficient variance). Values were corrected for dose, assuming that all patients received 20 mg of oxycodone. *Paired t-test for difference between logarithmic geometric means (two-sided).