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A single amino acid at the PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex.

NIAID Data Ecosystem2026-05-01 收录

白血病分子机制

蛋白质-复合物相互作用

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200393 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-09-27

白血病分子机制

基因表达谱分析

Background: MLL (KMT2A)-EB1 (MAPRE1) fusion was identified in a patient with de novo pro-B acute lymphoblastic leukemia. To investigate the leukemogenesis of MLL-EB1 fusion, a retroviral transduction

NIAID Data Ecosystem100

Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia [ChIP-Seq]. Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia [ChIP-Seq]

白血病分子机制

YEATS结构域靶向治疗

Transcriptional co-regulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic l

NIAID Data Ecosystem60

EGAS00001000058-sc-20130718a - samples

白血病分子机制

基因组学测序

The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblastic leukemia (ALL), is acquired in utero but requires additional somatic mutations for overt leukemia. We used exome and low-cover

NIAID Data Ecosystem40

TAF1 is critical for AE driven leukemogenesis [RNA-seq]

白血病分子机制

RNA-seq基因表达

TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate

NIAID Data Ecosystem80

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis

白血病分子机制

激酶-转录调控

The significance of MYC deregulation has been well-documented in T-cell acute lymphoblastic leukemia (T-ALL). MYC acts as an oncogenic driver in T-ALL and particularly in maintaining leukemia-initiati

NIAID Data Ecosystem50

A single amino acid at the PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex.

资源简介：

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